A German neurologist, Dr. Alois Alzheimer, made the discovery of the hallmarks of this disease in 1905. Four years previously, a woman came under his care. She suffered from memory loss, bouts of confusion, difficulty speaking, agitation, suspicions, wandering and screaming when confined to her bed. He studied her behavior patterns and physical health until her death in 1905 whereupon he performed an autopsy on her brain.